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In silico investigation of binding propensity of hematoxylin derivative and damnacanthal for their potential inhibitory effect on HIV-1 Vpr from different subtypes.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Datta Joyeeta, Majumder Satyabrata, Chaudhuri Dwaipayan, Giri Kalyan

Abstract excerpt

HIV-1, the causative agent of AIDS leads to many deaths worldwide though few options are available as therapeutics. To deal with the continuous mutation in the virus genome, requirement of new drugs is always there. Subtype variation plays a crucial role in case of HIV-1 therapeutics development. In this study, we want to investigate some pre examined molecules that can be effective for HIV-1 VPR. Inhibition of...

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PMID: 36858595
DOI: 10.1080/07391102.2023.2184634

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