Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Traditional Chinese medicine application in HIV: an<i>in silico</i>study

20 Dec 2012

Abstract excerpt

Viral infection by human immunodeficiency virus (HIV) requires integration of viral DNA with host DNA which involves the binding of HIV integrase (IN) with its co-factor lens epithelium-derived growth factor (LEDGF/p75). Since disrupted binding of IN with LEDGF/p75 inhibits proliferation of HIV, inhibition or denaturation of IN is a possible method for inhibiting HIV replication. D77 is a known drug with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Toxin Mechanisms and Immunotoxins
Share to Traditional Chinese Medicine Studies
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23252879
DOI: 10.1080/07391102.2012.745168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Traditional Chinese medicine application in HIV: an<i>in silico</i>studyPMID 23252879Read ↗

Structure-based virtual screening toward the discovery of novel inhibitors for impeding the protein-protein interaction between HIV-1 integrase and human lens epithelium-derived growth factor (LEDGF/p75)Semantic proximity Read ↗

Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations.Semantic proximity Read ↗

Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75Semantic proximity Read ↗

Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitorsSemantic proximity Read ↗

Development of Anti-HIV Therapeutics: From Conventional Drug Discovery to Cutting-Edge TechnologySemantic proximity Read ↗

Antiviral Activity of an Indole-Type Compound Derived from Natural Products, Identified by Virtual Screening by Interaction on Dengue Virus NS5 ProteinSemantic proximity Read ↗

In silico investigation of binding propensity of hematoxylin derivative and damnacanthal for their potential inhibitory effect on HIV-1 Vpr from different subtypes.Semantic proximity Read ↗

In-silico Screening of <i>Origanum vulgare</i> Phytocompounds as Potential Drug Agents Against <i>Vp35</i> Protein of the Ebola VirusSemantic proximity Read ↗

Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network-molecular docking-LC–MSE analysisSemantic proximity Read ↗

Towards the de Novo Design of HIV-1 Protease Inhibitors Based on Natural ProductsSemantic proximity Read ↗

From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infectionSemantic proximity Read ↗

Computer-Aided Algorithmic Approaches to Drug Development for Multi-Mutant HIV-1 Reverse Transcriptase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.