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Article

State- and stimulus-specific dynamics of SMAD signaling determine fate decisions in individual cells

1 Mar 2023

Abstract excerpt

SMAD-mediated signaling regulates apoptosis, cell cycle arrest, and epithelial-to-mesenchymal transition to safeguard tissue homeostasis. However, it remains elusive how the relatively simple pathway can determine such a broad range of cell fate decisions and how it differentiates between varying ligands. Here, we systematically investigate how SMAD-mediated responses are modulated by various ligands of the...

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PMID: 36857347
DOI: 10.1073/pnas.2210891120

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