Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis

28 Feb 2023

Abstract excerpt

Abstract Background Although the relationship between type 2 diabetes (T2D) and the increased risk of colorectal carcinogenesis is widely defined in clinical studies, the therapeutic methods and molecular mechanism of T2D-induced colon cancer and how does hyperglycemia affect the progression is still unknown. Here, we studied the function of lactoferrin (LF) in suppressing the progression of colon cancer in T2D...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Ferroptosis and cancer prognosis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36855062
DOI: 10.1186/s12967-023-03983-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axisPMID 36855062Read ↗

Fucosyltransferases Regulated by Fusobacterium Nucleatum Promote the Progression of Colon AdenocarcinomaSemantic proximity Read ↗

Specific deletion of Mettl3 in IECs triggers the development of spontaneous colitis and dysbiosis of T lymphocytes in miceSemantic proximity Read ↗

LncRNA ANRIL promotes glucose metabolism and proliferation of colon cancer in a high-glucose environment and associated with worse outcome in diabetic colon cancer patientsSemantic proximity Read ↗

The m6A methyltransferase METTL3 modifies Kcnk6 promoting on inflammation associated carcinogenesis is essential for colon homeostasis and defense system through histone lactylation dependent YTHDF2 bindingSemantic proximity Read ↗

WTAP regulates autophagy in colon cancer cells by inhibiting FLNA through N6-methyladenosineSemantic proximity Read ↗

Intestinal cancer development in response to oral infection with high-fat diet induced type 2 diabetes in collaborative cross mice under different host genetic background effectsSemantic proximity Read ↗

Diabetes associated with abnormal p53 immunohistochemical patterns in colorectal cancerSemantic proximity Read ↗

Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancerSemantic proximity Read ↗

Lipocalin 2 potentially contributes to tumorigenesis from colitis via IL-6/STAT3/NF-κB signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.