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Article

Analysis of KRAS Mutations in Gastrointestinal Tract Adenocarcinomas Reveals Site-Specific Mutational Signatures.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2023

Wang Linyuan, Saeedi Bejan J, Mahdi Zaid, Krasinskas Alyssa, Robinson Brian

Abstract excerpt

Adenocarcinomas of the luminal gastrointestinal tract and pancreatobiliary system often show histologic and immunohistochemical overlap, making delineation of the primary site in a metastatic setting difficult. Previous studies have shown that site-specific missense mutations in the oncogene KRAS could be used in conjunction with immunohistochemistry to differentiate metastatic pancreatic adenocarcinoma from...

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Source

Identifiers

PMID: 36853786
DOI: 10.1016/j.modpat.2022.100014

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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