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Article

Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins.

Cell reports - 29 Oct 2019

Dunne Matthew, Rupf Beatrice, Tala Marc, Qabrati Xhem, Ernst Patrick, Shen Yang, Sumrall Eric, Heeb Laura, Plückthun Andreas, Loessner Martin J, Kilcher Samuel

Abstract excerpt

Bacteriophages provide excellent tools for diagnostics, remediation, and targeted microbiome manipulation, yet isolating viruses with suitable host specificity remains challenging. Using Listeria phage PSA, we present a synthetic biology blueprint for host-range engineering through targeted modification of serovar-specific receptor binding proteins (RBPs). We identify Gp15 as the PSA RBP and construct a synthetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31665644
DOI: 10.1016/j.celrep.2019.09.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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