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Article

Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage.

Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2023

Bussotti Giovanni, Li Blaise, Pescher Pascale, Vojtkova Barbora, Louradour Isabelle, Pruzinova Katerina, Sadlova Jovana, Volf Petr, Späth Gerald F

Abstract excerpt

Trypanosomatid pathogens are transmitted by blood-feeding insects, causing devastating human infections. These parasites show important phenotypic shifts that often impact parasite pathogenicity, tissue tropism, or drug susceptibility. The evolutionary mechanisms that allow for the selection of such adaptive phenotypes remain only poorly investigated. Here, we use Leishmania donovani as a trypanosomatid model...

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Identifiers

PMID: 36848551
DOI: 10.1073/pnas.2220828120
PMCID: PMC10013807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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