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Article

The RUNX Family Defines Trk Phenotype and Aggressiveness of Human Neuroblastoma through Regulation of p53 and MYCN.

Cells - 8 Feb 2023

Ando Kiyohiro, Nakagawara Akira

Abstract excerpt

The Runt-related transcription factor (RUNX) family, which is essential for the differentiation of cells of neural crest origin, also plays a potential role in neuroblastoma tumorigenesis. Consecutive studies in various tumor types have demonstrated that the RUNX family can play either pro-tumorigenic or anti-tumorigenic roles in a context-dependent manner, including in response to chemotherapeutic agents....

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PMID: 36831211
DOI: 10.3390/cells12040544
PMCID: PMC9954111

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