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Article

Mutations in PGRN gene associated with the risk of psoriasis in Pakistan: a case control study.

BMC medical genomics - 21 Dec 2023

Saleem Saima, Imran Zunaira, Samdani Azam, Khoso Bahram, Zehra Sitwat, Azhar Abid

Abstract excerpt

BACKGROUND: Psoriasis is a chronic, autoimmune, papulosquamous skin disorder, characterized by the formation of drop-like papules and silvery-white plaques surrounded by reddened or inflamed skin, existing predominantly on the scalp, knees and elbows. The characteristic inflammation and hyperproliferation of keratinocytes in psoriasis is regulated by progranulin (PGRN), which suppresses the expression and release...

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PMID: 38129828
DOI: 10.1186/s12920-023-01757-8
PMCID: PMC10740244

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