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Ethanol consumption favors pro-contractile phenotype of perivascular adipose tissue: A role for interleukin-6.

Life sciences - 15 Apr 2023

Simplicio Janaina A, Dourado Thales M H, Awata Wanessa M C, do Vale Gabriel T, Dias Vinícius R, Barros Paula R, de Martinis Bruno S, Tostes Rita C, Tirapelli Carlos R

Abstract excerpt

Perivascular adipose tissue (PVAT) exerts anticontractile effect, but under non-physiological conditions it may contribute to vascular dysfunction by releasing pro-inflammatory cytokines. Since PVAT is an important source of interleukin (IL)-6, we evaluated whether this cytokine would contribute to ethanol-induced vascular dysfunction. With this purpose, male C57BL/6 wild-type (WT) or IL-6-deficient mice...

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PMID: 36828130
DOI: 10.1016/j.lfs.2023.121526

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