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Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis

21 Feb 2023

Abstract excerpt

BACKGROUND: The viral G-protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein-Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells. MHC-I downregulation, which presumably occurs through co-internalization with EBV-BILF1, is preserved among BILF1 receptors, including the three BILF1 orthologs encoded by porcine lymphotropic herpesviruses...

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PMID: 36810008
DOI: 10.1186/s11658-023-00427-y

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