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Natural Cycloartane Triterpenoids from Corypha utan Lamk. with Anticancer Activity towards P388 Cell Lines and their Predicted Interaction with FLT3.

Combinatorial chemistry & high throughput screening - 1 Jan 2023

Heliawati Leny, Kurnia Dikdik, Apriyanti Eti, Adinda Adrian Syah Putri Nabila, Lotebulo Ndruru Sun Theo Constan

Abstract excerpt

BACKGROUND: Cancer is the second leading cause of death in the world. Leukemia is a type of cancer that accounts for 31.5% of all cancers in children under the age of 15 in industrialized countries and 15.7% in developing countries. The inhibition of FMS-like tyrosine kinase 3 (FLT3) is a suitable approach for acute myeloid leukemia (AML) therapy as it is overexpressed in AML. AIM AND OBJECTIVE: This study...

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PMID: 36809943
DOI: 10.2174/1386207326666230210141218

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