Article

Discovery of natural compounds as novel FMS-like tyrosine kinase-3 (FLT3) therapeutic inhibitors for the treatment of acute myeloid leukemia: an <i>in silico</i> approach

2024-08-29

Abstract excerpt

<h4>ABSTRACT</h4> FLT3 mutations, observed in approximately 30-35% of Acute Myeloid Leukemia (AML) cases, drive leukemic proliferation and survival pathways, presenting a significant challenge in clinical management. To address this therapeutic need, we employed a comprehensive computational approach integrating pharmacophore screening, molecular docking, ADMET analysis, and molecular dynamics simulations to iden...

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Literature Corpus work: dcdebbed-e26f-57e9-8d54-de1d190e88cf
DOI: 10.1101/2024.08.27.609927

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