Article
KRT5 mutation regulate melanin metabolism through notch signalling pathway between keratinocytes and melanocytes.
Experimental dermatology - 1 Jun 2023
Jia Weixue, Zhang Yuanyuan, Wang Xue, Luo Lingling, Sun Heng, Jiang Yiqun, Wang Jianbo, Mao Qiuxia, Guo Youming, Kong Lingzhuo, Mo Ran, Li Chengrang
Abstract excerpt
Dowling-Degos disease (DDD) is an autosomal dominant hereditary skin disease characterized by acquired reticular hyperpigmentation in flexural sites, and one of its causative genes is KRT5 gene. But the effect of KRT5, expressed only in keratinocytes, on melanocytes is unclear. Other pathogenic genes of DDD include POFUT1, POGLUT1 and PSENEN genes, which is involved in posttranslational modification of Notch...
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