Beneath the surface: delineating the subtypes of Dowling-Degos disease.

Abstract excerpt

Dowling-Degos disease (DDD) is a rare, genetically heterogeneous pigmentation disorder with an autosomal dominant pattern of inheritance. While DDD shows wide clinical variability, a defining feature is reticulate hyperpigmentation, which typically emerges after puberty and worsens progressively thereafter. Additionally, affected individuals may experience symptoms such as itching, burning and/or inflammatory...

Topics

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• Genetic Predisposition to Disease
• Hyperpigmentation
• Keratin-5
• Mutation
• Phenotype