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Article

Neurological soft signs are increased in major depressive disorder irrespective of treatment.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Apr 2023

Schülke Rasmus, Liepach Kyra, Brömstrup Anna Lena, Folsche Thorsten, Deest Maximilian, Bleich Stefan, Neyazi Alexandra, Frieling Helge, Maier Hannah B

Abstract excerpt

The significance of neurological soft signs (NSS) in major depressive disorder (MDD) remains unclear and the stability of NSS in relation to antidepressant treatment has never been investigated. We hypothesized that NSS are relatively stable trait markers of MDD. We thus predicted that patients show more NSS than healthy controls, irrespective of illness duration and antidepressant treatment. To test this...

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Identifiers

PMID: 36801977
DOI: 10.1007/s00702-023-02602-z
PMCID: PMC10050027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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