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Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging

16 Feb 2023

Abstract excerpt

Ischemic heart disease (IHD) is the leading cause of death, with age range being the primary factor for development. The mechanisms by which aging increases vulnerability to ischemic insult are not well understood. We aim to use single-cell RNA sequencing to discover transcriptional differences in various cell types between aged and young mice, which may contribute to aged-related vulnerability to ischemic...

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PMID: 36797808
DOI: 10.1111/acel.13800

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