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Article

DNA repair deficiency as circulating biomarker in prostate cancer

30 Jan 2023

Abstract excerpt

is the most frequently altered DDR gene in this tumor. Poly ADP-ribose polymerase inhibitors showed antitumor activity with a improvement in overall survival in mCRPC carrying somatic and/or germline alterations of HHR. Germline mutations are tested on peripheral blood samples using DNA extracted from peripheral blood leukocytes, while the somatic alterations are assessed by extracting DNA from a tumor tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36793600
DOI: 10.3389/fonc.2023.1115241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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