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Article

Clinical assays for assessment of homologous recombination DNA repair deficiency.

Gynecologic oncology - 1 Dec 2020

Stover Elizabeth H, Fuh Katherine, Konstantinopoulos Panagiotis A, Matulonis Ursula A, Liu Joyce F

Abstract excerpt

Homologous recombination DNA repair deficiency (HRD) is a functional defect in homologous recombination DNA repair, arising from germline or somatic mutations in BRCA1/2 or other mechanisms. Cells with HRD are more sensitive to platinum and poly(ADP-ribose) polymerase inhibitors (PARPi). HRD generates permanent changes in the genome with specific, quantifiable patterns ("genomic scars"). Clinical tests for HRD,...

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Identifiers

PMID: 33012552
DOI: 10.1016/j.ygyno.2020.09.029

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