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FGF Signaling in Lung Development and Disease: Human Versus Mouse

12 Mar 2019

Abstract excerpt

Fibroblast growth factor 10 (FGF10) plays an important role in mouse lung development, injury, and repair. It is considered the main morphogen driving lung branching morphogenesis in rodents. While many studies have found FGF10 SNPs associated with COPD and branch variants in COPD smokers, there is no evidence of a causative role for FGF10 or these SNPs in human lung development and pediatric lung diseases. We...

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PMID: 30930931
DOI: 10.3389/fgene.2019.00170

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