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Genetic association of PRKCD and CARD9 polymorphisms with Vogt-Koyanagi-Harada disease in the Chinese Han population.

Human genomics - 13 Feb 2023

Zhou Chunya, Cai Shiya, Xie Yuhong, Zeng Zhen, Zhang Jun, Su Guannan, Wu Qiuying, Ye Xingsheng, Cao Qingfeng, Yang Peizeng, Hu Jianmin

Abstract excerpt

BACKGROUND: Protein kinase C delta (PRKCD) and caspase recruitment domain family member 9 (CARD9) are genes involved in B and T cell activation, and cytokine production, which are vital mechanisms underlying autoimmune disease development. This study aimed to explore the association of the PRKCD and CARD9 genes with Vogt-Koyanagi-Harada disease (VKH) disease. The case-control study was performed to in 912...

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Identifiers

PMID: 36782298
DOI: 10.1186/s40246-023-00459-7
PMCID: PMC9926551

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