Article
Clinical significance of circulating-tumour DNA analysis by metastatic sites in pancreatic cancer.
British journal of cancer - 1 Apr 2023
Umemoto Kumiko, Sunakawa Yu, Ueno Makoto, Furukawa Masayuki, Mizuno Nobumasa, Sudo Kentaro, Kawamoto Yasuyuki, Kajiwara Takeshi, Ohtsubo Koushiro, Okano Naohiro, Matsuhashi Nobuhisa, Itoh Shinji, Matsumoto Toshihiko, Shimizu Satoshi, Otsuru Toru, Hasegawa Hiroko, Okuyama Hiroyuki, Ohama Hideko, Moriwaki Toshikazu, Ohta Takashi, Odegaard Justin I, Nakamura Yoshiaki, Bando Hideaki, Yoshino Takayuki, Ikeda Masafumi, Morizane Chigusa
Abstract excerpt
BACKGROUND: Liquid biopsy is an alternative to tissue specimens for tumour genotyping. However, the frequency of genomic alterations with low circulating-tumour DNA (ctDNA) shedding is shown in pancreatic ductal adenocarcinoma (PDAC). We, therefore, investigated the prevalence of KRAS mutations and ctDNA fraction by the metastatic site in patients with PDAC. METHODS: This study enrolled previously treated PDAC...
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