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Article

Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives

1 Jan 2025

Abstract excerpt

Background: Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic adenosine monophosphate (cAMP) response element modulator (CREM) playing a pivotal role in testicular function. Understanding the interplay between T2D and...

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PMID: 40474948
DOI: 10.1002/rmb2.12661

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