Article
Transcriptional Networks in Epithelial-Mesenchymal Transition
30 Sept 2011
Abstract excerpt
BACKGROUND: Epithelial-mesenchymal transition (EMT) changes polarized epithelial cells into migratory phenotypes associated with loss of cell-cell adhesion molecules and cytoskeletal rearrangements. This form of plasticity is seen in mesodermal development, fibroblast formation, and cancer metastasis. METHODS AND FINDINGS: Here we identify prominent transcriptional networks active during three time points of this...
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