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Article

New Mutations in DNHD1 Cause Multiple Morphological Abnormalities of the Sperm Flagella.

International journal of molecular sciences - 29 Jan 2023

Martinez Guillaume, Barbotin Anne-Laure, Cazin Caroline, Wehbe Zeina, Boursier Angèle, Amiri-Yekta Amir, Daneshipour Abbas, Hosseini Seyedeh-Hanieh, Rives Nathalie, Feraille Aurélie, Thierry-Mieg Nicolas, Bidart Marie, Satre Véronique, Arnoult Christophe, Ray Pierre F, Kherraf Zine-Eddine, Coutton Charles

Abstract excerpt

Male infertility is a common and complex disease and presents as a wide range of heterogeneous phenotypes. Multiple morphological abnormalities of the sperm flagellum (MMAF) phenotype is a peculiar condition of extreme morphological sperm defects characterized by a mosaic of sperm flagellum defects to a total asthenozoospermia. At this time, about 40 genes were associated with the MMAF phenotype. However,...

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Identifiers

PMID: 36768883
DOI: 10.3390/ijms24032559
PMCID: PMC9916431

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