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Article

Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study.

BMC cancer - 10 Feb 2023

Zhang Yanxi, Zhang Han, Zhu Jinghan, He Yazhou, Wang Peng, Li Doudou, Liu Xiaozhuan, Jin Wen, Zhang Junxi, Xu Chuan, Yu Zengli, Zhao Xin, Cui Lingling

Abstract excerpt

BACKGROUND: Diverticular disease has been inconsistently associated with colorectal cancer risk. We conducted a bidirectional Mendelian randomization study to assess this association. METHODS: Forty-three and seventy single-nucleotide polymorphisms associated with diverticular disease and colorectal cancer at the genome-wide significance level (p < 5 × 10- 8) were selected as instrumental variables from...

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Identifiers

PMID: 36765336
DOI: 10.1186/s12885-023-10606-x
PMCID: PMC9912649

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