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In silico prediction of molecular mechanisms of toxicity mediated by the leptospiral PF07598 gene family-encoded virulence-modifying proteins

23 Jan 2023

Abstract excerpt

Mechanisms of leptospirosis pathogenesis remain unclear despite the identification of a number of potential leptospiral virulence factors. We recently demonstrated potential mechanisms by which the virulence-modifying (VM) proteins—defined as containing a Domain of Unknown function (DUF1561), encoded by the PF07598 gene family—found only in group 1 pathogenic Leptospira —might mediate the clinical pathogenesis of...

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PMID: 36756251
DOI: 10.3389/fmolb.2022.1092197

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