Article
CD103 blockade impair anti-CTLA-4 immunotherapy in oral cancer.
Oral oncology - 1 Mar 2023
Xiao Yao, Mao Liang, Yang Qi-Chao, Wang Shuo, Wu Zhi-Zhong, Wan Shu-Cheng, Zhang Meng-Jie, Sun Zhi-Jun
Abstract excerpt
OBJECTIVES: CD103+CD8+T cells is a subtype of T cells with excellent tumor killing ability and it could response to immune checkpoint blockade therapy in several types of cancer, but the phenotype, role and molecular mechanism CD103+CD8+T cells in the OSCC still unclear. MATERIALS AND METHODS: The distribution and phenotype of CD103+CD8+T cells were investigated by performing multiplexed immunohistochemistry on...
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