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Article

Real-world clinical utility of comprehensive genomic profiling in advanced solid tumors.

Nature medicine - 1 Feb 2026

Saito Yuki, Horie Sara, Kogure Yasunori, Mizuno Kota, Ito Yuta, Mizukami Yosuke, Kim Haryoon, Tamura Zen, Koya Junji, Funakoshi Takeru, Hirata Kenro, Kataoka Keisuke

Abstract excerpt

Comprehensive genomic profiling (CGP) is crucial in precision oncology, yet its real-world utility remains unclear. Here we analyzed data from the Japanese nationwide Center for Cancer Genomics and Advanced Therapeutics database, including clinical and genetic data from 54,185 patients with advanced solid tumors (consisting of 81 common and rare tumor types) who received CGP with a targeted sequencing panel...

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Identifiers

PMID: 41495408
DOI: 10.1038/s41591-025-04086-8
PMCID: PMC12920123

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