Article
DNTT activation, TdT-aided gene length mutation, and better prognosis in ATG-based regimen allo-HSCT in AML.
Molecular carcinogenesis - 1 May 2023
Zhou Xiaosu, Nie Daijing, Zhang Yang, Liu Zhixiu, Zhao Yanli, Zhang Jianping, Wang Fang, Fang Jiancheng, Cao Panxiang, Chen Xue, Ma Xiaoli, Yuan Lili, Chen Jiaqi, Tan Yincheng, Chen Qihui, Liu Ming, Liu Mingyue, Liu Yijun, Wu Qisheng, Lu Peihua, Liu Hongxing
Abstract excerpt
This study aimed to investigate the relationship between anomalous DNA nucleotidylexotransferase (DNTT) activation and the mutagenesis of gene length mutations (LMs) in acute myeloid leukemia (AML), and the relevance of their prognosis in antithymocyte globulin (ATG)-based regimen allogeneic hematopoietic stem cell transplantation (allo-HSCT). A cohort of 578 AML cases was enrolled. Next-generation sequencing was...
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