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Is it bad, is it good, or is IgG4 just misunderstood?

7 Feb 2023

Abstract excerpt

Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and NK cell–dependent elimination of infected cells (see related Research...

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PMID: 36749191
DOI: 10.1126/sciimmunol.adg7327

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