Article

The landscape of reported VUS in multi-gene panel and genomic testing: Time for a change

2022-09-22

Abstract excerpt

<h4>PURPOSE</h4> Variants of uncertain significance (VUS) are a common result of diagnostic genetic testing and can be difficult to manage with potential misinterpretation and downstream costs, including time investment by clinicians. We investigated the rate of VUS reported on diagnostic testing via multi-gene panels (MGPs) and exome and genome sequencing (ES/GS) to measure the magnitude of uncertain results and...

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Literature Corpus work: c9564436-2985-57aa-9248-43fd6089b694
DOI: 10.1101/2022.09.21.22279949

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