Article
A single mutation in Crimean-Congo hemorrhagic fever virus discovered in ticks impairs infectivity in human cells.
eLife - 21 Oct 2020
Hua Brian L, Scholte Florine Em, Ohlendorf Valerie, Kopp Anne, Marklewitz Marco, Drosten Christian, Nichol Stuart T, Spiropoulou Christina, Junglen Sandra, Bergeron Éric
Abstract excerpt
Crimean-Congo hemorrhagic fever (CCHF) is the most widely distributed tick-borne viral infection in the world. Strikingly, reported mortality rates for CCHF are extremely variable, ranging from 5% to 80% (Whitehouse, 2004). CCHF virus (CCHFV, Nairoviridae) exhibits extensive genomic sequence diversity across strains (Deyde et al., 2006; Sherifi et al., 2014). It is currently unknown if genomic diversity is a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.