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Article

Atypical Molecular Features of Pediatric Tectal Glioma: A Single Institutional Series.

Journal of pediatric hematology/oncology - 1 Apr 2023

Yakir Maayan Joy, Elster Jennifer D, Paul Megan R, Khanna Paritosh C, Malicki Denise M, Levy Michael L, Crawford John Ross

Abstract excerpt

We present 4 children (diagnosed between 1 and 8 y, 3 females and 1 male) with molecularly distinct tectal gliomas (2 KRAS mutant, 1 EGFR mutant, 1 SRGAP3-RAF-1 fusion) that contributes to the growing literature of this uncommonly biopsied tumor. The patient with EGFR R222C mutation had a more severe course, earlier diagnosis, subsequent leptomeningeal metastatic disease, required more aggressive therapies, and...

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PMID: 36730386
DOI: 10.1097/MPH.0000000000002596

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