Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures.

doi:10.1136/jnnp-2022-330713

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Article

Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures.

Journal of neurology, neurosurgery, and psychiatry - 1 Jul 2023

Nasr Zahra, Schoeps Vinicius Andreoli, Ziaei Amin, Virupakshaiah Akash, Adams Cameron, Casper T Charles, Waltz Michael, Rose John, Rodriguez Moses, Tillema Jan-Mendelt, Chitnis Tanuja, Graves Jennifer S, Benson Leslie, Rensel Mary, Krupp Lauren, Waldman Amy T, Weinstock-Guttman Bianca, Lotze Tim, Greenberg Benjamin, Aaen Gregory, Mar Soe, Schreiner Teri, Hart Janace, Simpson-Yap Steve, Mesaros Clementina, Barcellos Lisa F, Waubant Emmanuelle

Abstract excerpt

BACKGROUND: We previously reported an association between household chemical exposures and an increased risk of paediatric-onset multiple sclerosis. METHODS: Using a case-control paediatric multiple sclerosis study, gene-environment interaction between exposure to household chemicals and genotypes for risk of paediatric-onset multiple sclerosis was estimated.Genetic risk factors of interest included the two major...

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Identifiers

PMID: 36725329
DOI: 10.1136/jnnp-2022-330713
PMCID: PMC10272045

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