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Article

Overexpression of mTOR in Leukocytes from ALS8 Patients.

Current neuropharmacology - 1 Jan 2023

Gomes Nathália Augusta, das Chagas Lima E Silva Francisco, de Oliveira Volpe Caroline Maria, Villar-Delfino Pedro Henrique, de Sousa Camila Ferreira, Rocha-Silva Fabiana, Nogueira-Machado José Augusto

Abstract excerpt

BACKGROUND: The mutated VAPBP56S (vesicle B associated membrane protein - P56S) protein has been described in a Brazilian family and classified as Amyotrophic Lateral Sclerosis type 8 (ALS8). OBJECTIVE: We aimed to study altered biochemical and immunological parameters in cells from ALS8 patients to identify possible biomarkers or therapeutic targets. METHODS: Wild-type VAPB, VAPBP56S, mTOR, proinflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36722478
DOI: 10.2174/1570159X21666230201151016
PMCID: PMC10207909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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