Article
Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on cognition in women with high familial risk of ovarian cancer: A cross-sectional study.
BJOG : an international journal of obstetrics and gynaecology - 1 Jul 2023
Terra Lara, Lee Meeuw Kjoe Philippe R, Agelink van Rentergem Joost A, Beekman Maarten J, Heemskerk-Gerritsen Bernadette A M, van Beurden Marc, Roeters van Lennep Jeanine E, van Doorn Helena C, de Hullu Joanna A, Mourits Marian J E, van Dorst Eleonora B L, Mom Constantijne H, Slangen Brigitte F M, Gaarenstroom Katja N, van der Kolk Lizet E, Collée J Margriet, Wevers Marijke R, Ausems Margreet G E M, van Engelen Klaartje, van de Beek Irma, Berger Lieke P V, van Asperen Christi J, Gomez Garcia Encarna B, Maas Angela H E M, Hooning Maartje J, van der Wall Elsken, van Leeuwen Flora E, Schagen Sanne B
Abstract excerpt
OBJECTIVE: To examine the effect of a premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. DESIGN: A cross-sectional study with prospective follow-up, nested in a nationwide cohort. SETTING: Multicentre in the Netherlands. POPULATION OR SAMPLE: 641 women (66% BRCA1/2 pathogenic variant carriers)...
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