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Article

Testis-enriched ferlin, FER1L5, is required for Ca 2+ -activated acrosome reaction and male fertility

25 Jan 2023

Abstract excerpt

Spermatozoa need to undergo an exocytotic event called the acrosome reaction before fusing with eggs. Although calcium ion (Ca 2+ ) is essential for the acrosome reaction, its molecular mechanism remains unknown. Ferlin is a single transmembrane protein with multiple Ca 2+ -binding C2 domains, and there are six ferlins, dysferlin (DYSF), otoferlin (OTOF), myoferlin (MYOF), fer-1–like 4 (FER1L4), FER1L5, and...

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PMID: 36696506
DOI: 10.1126/sciadv.ade7607

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