Article
Urtica dioica agglutinin (UDA) as a potential candidate for inhibition of SARS-CoV-2 Omicron variants: In silico prediction and experimental validation.
Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Mar 2023
Sabzian-Molaei Fatemeh, Hosseini Seyedrafi, Alipour Atefeh, Ghaderi Hajarossadat, Fotouhi-Chahouki Fatemeh, Hadi Amin, Shahsavarani Hosein
Abstract excerpt
BACKGROUND: The high number of mutations and consequent structure modifications in a Receptor-Binding Domain (RBD) of the spike protein of the Omicron variant of SARS-CoV-2 increased concerns about evading neutralization by antibodies induced by previous infection or vaccination. Thus, developing novel drugs with potent inhibitory activity can be considered an alternative for treating this highly transmissible...
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