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In Silico Screening of Bioactive Compounds of Representative Seaweeds to Inhibit SARS-CoV-2 ACE2-Bound Omicron B.1.1.529 Spike Protein Trimer.

Marine drugs - 17 Feb 2022

Bharathi Muruganantham, Sivamaruthi Bhagavathi Sundaram, Kesika Periyanaina, Thangaleela Subramanian, Chaiyasut Chaiyavat

Abstract excerpt

Omicron is an emerging SARS-CoV-2 variant, evolved from the Indian delta variant B.1.617.2, which is currently infecting worldwide. The spike glycoprotein, an important molecule in the pathogenesis and transmissions of SARS-CoV-2 variants, especially omicron B.1.1.529, shows 37 mutations distributed over the trimeric protein domains. Notably, fifteen of these mutations reside in the receptor-binding domain of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35200677
DOI: 10.3390/md20020148
PMCID: PMC8877529

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