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Article

Mutation of Basic Residues R283, R286, and K288 in the Matrix Protein of Newcastle Disease Virus Attenuates Viral Replication and Pathogenicity.

International journal of molecular sciences - 4 Jan 2023

Duan Zhiqiang, Shi Haiying, Xing Jingru, Zhang Qianyong, Liu Menglan

Abstract excerpt

The matrix (M) protein of Newcastle disease virus (NDV) contains large numbers of unevenly distributed basic residues, but the precise function of most basic residues in the M protein remains enigmatic. We previously demonstrated that the C-terminus (aa 264-313) of M protein interacted with the extra-terminal (ET) domain of chicken bromodomain-containing protein 2 (chBRD2), which promoted NDV replication by...

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PMID: 36674496
DOI: 10.3390/ijms24020980
PMCID: PMC9864103

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