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Integration analysis of pituitary proteome and transcriptome reveals fertility-related biomarkers in FecB mutant Small Tail Han sheep.

Frontiers in endocrinology - 1 Jan 2024

Wang Xiangyu, Guo Xiaofei, He Xiaoyun, Di Ran, Zhang Xiaosheng, Zhang Jinlong, Chu Mingxing

Abstract excerpt

The Booroola fecundity mutation (FecB) in Small Tail Han sheep has been shown to enhance ovulation rates and litter sizes by affecting the hypothalamic-pituitary-gonadal (HPG) axis. Despite the pituitary's role in reproductive regulation, its involvement in FecB-induced ovulation remains understudied. Our study aimed to fill this gap by analyzing pituitary tissues from FecB homozygous (BB) and wild-type (WW) ewes...

Topics

Animals
Female
Sheep
Fertility
Pituitary Gland
Proteome
Transcriptome
Biomarkers
Mutation
Proteomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39109077
DOI: 10.3389/fendo.2024.1417530
PMCID: PMC11301337

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