Article
Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system.
eLife - 20 Jan 2023
Jean-Pierre Fabrice, Hampton Thomas H, Schultz Daniel, Hogan Deborah A, Groleau Marie-Christine, Déziel Eric, O'Toole George A
Abstract excerpt
Interspecies interactions can drive the emergence of unexpected microbial phenotypes that are not observed when studying monocultures. The cystic fibrosis (CF) lung consists of a complex environment where microbes, living as polymicrobial biofilm-like communities, are associated with negative clinical outcomes for persons with CF (pwCF). However, the current lack of in vitro models integrating the microbial...
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