Article
Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa.
Environmental microbiology - 1 May 2010
Klepac-Ceraj Vanja, Lemon Katherine P, Martin Thomas R, Allgaier Martin, Kembel Steven W, Knapp Alixandra A, Lory Stephen, Brodie Eoin L, Lynch Susan V, Bohannan Brendan J M, Green Jessica L, Maurer Brian A, Kolter Roberto
Abstract excerpt
Polymicrobial bronchopulmonary infections in cystic fibrosis (CF) cause progressive lung damage and death. Although the arrival of Pseudomonas aeruginosa often heralds a more rapid rate of pulmonary decline, there is significant inter-individual variation in the rate of decline, the causes of which remain poorly understood. By coupling culture-independent methods with ecological analyses, we discovered...
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