Article
Human-induced pluripotent stem cell-derived cerebral organoid of leukoencephalopathy with vanishing white matter.
CNS neuroscience & therapeutics - 1 Apr 2023
Deng Jiong, Zhang Jie, Gao Kai, Zhou Ling, Jiang Yuwu, Wang Jingmin, Wu Ye
Abstract excerpt
INTRODUCTION: Leukoencephalopathy with vanishing white matter (VWM) is a rare autosomal recessive leukoencephalopathy resulting from mutations in EIF2B1-5, which encode subunits of eukaryotic translation initiation factor 2B (eIF2B). Studies have found that eIF2B mutation has a certain influence on embryonic brain development. So far, the effect of the eIF2B mutations on the dynamic process of brain development...
Topics
- Humans
- Eukaryotic Initiation Factor-2B
- Induced Pluripotent Stem Cells
- Leukoencephalopathies
- Brain
- White Matter
- Mutation