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Association of AQP4 single nucleotide polymorphisms (rs335929 and rs2075575) with Parkinson's disease: A case-control study.

Neuroscience letters - 16 Feb 2023

Sun Xiaohui, Tian Qing, Yang Zhengjie, Liu Yumei, Li Chengqian, Hou Binghui, Xie Anmu

Abstract excerpt

OBJECTIVE: The glymphatic system plays an important role in brain waste removal and is functionally and structurally dependent on astrocyte aquaporin-4 (AQP4). Genetic variation in the AQP4 gene has therefore been hypothesized to be associated with genetic susceptibility to neurodegenerative diseases. This study aimed to investigate whether two specific single nucleotide polymorphisms (SNP) in the AQP4 gene,...

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PMID: 36626962
DOI: 10.1016/j.neulet.2023.137062

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