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Article

A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma.

Journal of translational medicine - 9 Jan 2023

Yu Lu-Lu, Hu Bi-Wen, Huang Han-Xue, Yu Bing, Xiao Qi, Lv Qiao-Li, Luo Chen-Hui, Guo Cheng-Xian, Li Jin-Gao, Xie Xiao-Xue, Yin Ji-Ye

Abstract excerpt

BACKGROUND: Radiotherapy (RT) is the standard treatment for nasopharyngeal carcinoma (NPC). However, due to individual differences in radiosensitivity, biomarkers are needed to tailored radiotherapy to cancer patients. However, comprehensive genome-wide radiogenomic studies on them are still lacking. The aim of this study was to identify genetic variants associated with radiotherapy response in patients with NPC....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36624463
DOI: 10.1186/s12967-022-03819-4
PMCID: PMC9830790

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