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Article

Mutational fitness landscape and drug resistance.

Current opinion in structural biology - 1 Feb 2023

Flynn Julia, Samant Neha, Schneider-Nachum Gily, Tenzin Tsepal, Bolon Daniel N A

Abstract excerpt

Robust technology has been developed to systematically quantify fitness landscapes that provide valuable opportunities to improve our understanding of drug resistance and define new avenues to develop drugs with reduced resistance susceptibility. We outline the critical importance of drug resistance studies and the potential for fitness landscape approaches to contribute to this effort. We describe the major...

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Identifiers

PMID: 36621152
DOI: 10.1016/j.sbi.2022.102525
PMCID: PMC10243218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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