Article
Molecular Mechanisms of Aggregation of Canine SOD1 E40K Amyloidogenic Mutant Protein.
Molecules (Basel, Switzerland) - 24 Dec 2022
Wakayama Kento, Kimura Shintaro, Kobatake Yui, Kamishina Hiroaki, Nishii Naohito, Takashima Satoshi, Honda Ryo, Kamatari Yuji O
Abstract excerpt
Canine degenerative myelopathy (DM) is a human amyotrophic lateral sclerosis (ALS)-like neurodegenerative disease. It is a unique, naturally occurring animal model of human ALS. Canine DM is associated with the aggregation of canine superoxide dismutase 1 (cSOD1), which is similar to human ALS. Almost 100% of cases in dogs are familial, and the E40K mutation in cSOD1 is a major causative mutation of DM....
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