Article
Hormone replacement therapy after menopause and risk of breast cancer in BRCA1 mutation carriers: a case-control study.
Breast cancer research and treatment - 1 Jan 2016
Kotsopoulos Joanne, Huzarski Tomasz, Gronwald Jacek, Moller Pal, Lynch Henry T, Neuhausen Susan L, Senter Leigha, Demsky Rochelle, Foulkes William D, Eng Charis, Karlan Beth, Tung Nadine, Singer Christian F, Sun Ping, Lubinski Jan, Narod Steven A
Abstract excerpt
Many BRCA1 mutation carriers undergo elective surgical oophorectomy (often before menopause) to manage their elevated risk of developing ovarian cancer. It is important to clarify whether or not the use of hormone replacement therapy (HRT) to mitigate the symptoms associated with surgical or natural menopause is safe in women with an inherited BRCA1 mutation and no personal history of breast or ovarian cancer. We...
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